The MCU has now reached a point where practically any installment shall be successful due to name brand recognition, so I, frankly, want to see it fail; it is a product of a giant soulless and tyrannical corporation, and everyone enjoys seeing giants fall from grace. I firmly believe that money cannot buy talent, but the very existence of the MCU is making it difficult for me to maintain that belief, and I also feel that it is smothering competition and leaving little room for new and innovative ideas. Currently, major franchises from major companies are dominating theaters, and I want to see something new and avant-garde from a small studio led by a young and amatuer director disrupt the status quo. I want to see innovation and risk taking, not more of the same formula that has been used and reused over the years, and I hope that other people share that desire.
We'll have to see how they handle the transition to "the next generation".
Of the original six Avengers, Iron Man, Captain America, and Black Widow seem to have been written out of the story for the foreseeable future, and the fate of Hulk is unclear. Only Thor and Hawkeye are still confirmed "active".
This means fans will have to bond with a new line-up of core characters and actors. If successful it could be as great as Dio replacing Ozzy. If unsuccessful it could be like Ian Gillan replacing Dio.