Tsunade takes them both. Although the Jyuuken system has the potential to be very damaging to her fighting style, Hinata herself is not strong enough to utilize it efficiently against an opponent of Tsunade's caliber, and the Hokage taught Sakura everything she knows. Her pupil still has a ways to go before before she catches up to her master, while Sakura has only shown a powerful punch, Tsunade has used her feet, hands, fingers. You would have to at least take away her summonings and Sozo Saisei to even it up a little, and even then, it wouldn't be enough to over come her experience.