konoha was hands down the strongest in the beggining when uchiha and senju clans formed. Hashirama gave the other villages tailed beasts which shows how powerful konoha was. Konoha always produced the best ninja compared to all other villages. No other village had anyone as strong as hashirama, minato, hiruzen and madara. Not to mention all the clans they have and the dojustsu clans like hyuga and uchiha. They also have the best justsu like edo tensei. They had other crazy ninjas such as itachi, naruto, the sanin, kakshi, guy and many others. It is also the village that has taken out most of atasuki. Even now after being severely weakened they still hold an edge in ninja quality.
The sanin would win with diffuculty they would win because mainly of the sage mode and also obecause orochimaru is almost unkillable and due to his vast jutsus and tsunade would just be backup. It would be pretty easy if orochimaru was allowed to use edo tensei though.