I have noticed how people love to say, that Hiraishin is instant kill, so anyone is doomed. Yet, they all fail to mention that hiraishin is anything but instant. Yondiame can't teleport just like that, there are a procedure he need to do before doing that.

The shairngan however is instant kill. The shairngan user only need to see your eyes and you are doomed. Even, if he doesn't see your eyes, he can turn you into ashes or send you to a another dimension with MS